Lisanne M. Spenkelink

The paper visualizes RRS function in vitro, showing gap formation during replisome passage and varying gap frequency based on strand positioning.

This study investigates how DNA supercoiling affects the activity of the restriction enzyme EcoRV at the single-molecule level using TIRF microscopy.

This paper introduces a DNA barcoding method to simultaneously profile kinetic properties of protein variants at the single-molecule level, revealing kinetic diversity and structural subpopulations.

This study optimizes nanobody-based quenchbodies for enhanced protein detection, achieving fluorescence increases of 1.5-2.4-fold and detecting IL-6 down to 2 nM.

This paper designs a DNA origami receptor that enables stable complexes with rapid subunit exchange, demonstrating the system's ability to handle both DNA and protein cargo.