Jonathan P. K. Doye

This study shows that base distribution along an invading strand strongly affects DNA-RNA strand displacement kinetics, enabling design of sequences with reaction rates spanning two orders of magnitude.

This study elucidates the structural diversity of S-layers across prokaryotes using AlphaFold2multimer and electron cryomicroscopy, revealing evolutionary patterns and cell anchoring mechanisms.

This paper develops a modular DNA origami voxel system capable of assembling into diverse 3D structures with high yield and reversible reconfiguration.

The paper designs proteins that form tunable assemblies in cells and maps their phase diagrams to understand how interactions influence mesoscale structures.

The paper designs and synthesizes pleated DNA origami nanotubes with adjustable diameters using a computational method for determining staple crossover locations.