Saharon Rosset

Widespread 3-Base Periodicity in Complex DNA Mixtures and an Alignment-Free Algorithm to Uncover its Source

The paper identifies a period-3 base frequency pattern in DNA mixtures and develops an alignment-free algorithm to uncover its origin, showing it results from sequence-dependent fragment formation rather than intrinsic DNA bias.

Collective Posterior Inference from Highly Variable Empirical Replicates

The paper introduces a method for fast and robust collective posterior inference from multiple noisy replicates, achieving state-of-the-art accuracy and efficiency.

The Warburg Effect is the result of faster ATP production by glycolysis than respiration

The paper shows glycolysis produces ATP faster per gram of protein than respiration in E. coli, yeast, and mammalian cells, explaining the Warburg Effect as an optimization of energy production rate under proteome constraints.

A scalable and robust variance components method reveals insights into the architecture of gene-environment interactions underlying complex traits

The paper introduces a variance components method to estimate gene-environment interaction heritability in complex traits using UK Biobank data, finding significant GxE effects for several trait-environment pairs.

Calling differential DNA methylation at cell-type resolution: addressing misconceptions and best practices

The paper benchmarks two methods for detecting cell-type-specific differential DNA methylation, finding TCA superior to CellDMC and discussing best practices for cell-type resolution analysis.

Cell-type-specific resolution epigenetics without the need for cell sorting or single-cell biology

The paper demonstrates a method to infer cell-type-specific DNA methylation from bulk data, revealing novel associations with leukocyte composition and rheumatoid arthritis.

Estimating Heritability and Genetic Correlation in Case Control Studies Directly and with Summary Statistics

This paper evaluates methods for estimating heritability and genetic correlation in case-control studies, finding that PCGC-s accurately handles non-genetic risk factors and provides unbiased estimates for schizophrenia and bipolar disorder.

RL-SKAT: An exact and efficient score test for heritability and set tests

RL-SKAT improves the accuracy of score tests for heritability and set-based genetic association by calculating exact p-values, avoiding the inflation or deflation of p-values seen in traditional methods.

Fast and accurate construction of confidence intervals for heritability

This paper introduces ALBI, a method for constructing accurate confidence intervals for heritability estimates using linear mixed models, addressing biases in existing approaches.