The paper reconstructs regulatory networks underlying trans-QTL hotspots using human multi-omics data and biological priors, identifying novel networks related to schizophrenia and lean body mass.

Genome Medicine · Nov 7, 2022Peer-reviewedBioinformatics

An integrative analysis of clinical and epigenetic biomarkers of mortality

Tianxiao Huan, Steve Nguyen, Elena Colicino, Carolina Ochoa‐Rosales, William David Hill, Jennifer A. Brody, Mette Soerensen, Yan Zhang, Antoine Baldassari, Mohamed A. Elhadad, Toshiko Tanaka, Yinan Zheng, Arce Domingo‐Relloso, Dong Heon Lee, Jiantao Ma, , Daniel A Levy

The paper integrates DNA methylation with clinical risk factors to improve mortality prediction, identifying CpG biomarkers associated with all-cause, cardiovascular, and cancer mortality.

Aging Cell · May 12, 2022Peer-reviewedGenetic & Genomic Medicine

A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter

Stefan Coassin, Natascha Hermann‐Kleiter, Margot Haun, Simone Wahl, Rory Wilson, Bernhard Paulweber, Sonja Kunze, Thomas Meitinger, Konstantin Strauch, Annette Peters, Mélanie Waldenberger, Florian Kronenberg, Claudia Lamina

The paper identifies a DNA methylation site in the LPA promoter associated with Lp(a) levels and shows that a SNP at this site influences Lp(a) through direct genetic effect, not methylation.

PLoS ONE · Apr 28, 2020Peer-reviewedGenetics

Epigenetic derepression of FKBP5 by aging and stress contributes to NF-kB-driven inflammation and cardiovascular risk

Anthony S. Zannas, Meiwen Jia, Kathrin Hafner, Jens J Baumert, Tobias Wiechmann, Julius C. Pape, Janine Arloth, Maik Ködel, Silvia Martinelli, Maria Roitman, Simone Röh, Andreas Haehle, Rebecca T. Emeny, Stella Iurato, Tania Carrillo‐Roa, , Elisabeth B. Binder

The paper identifies FKBP5 epigenetic derepression by aging and stress as a driver of NF-kB-driven inflammation and cardiovascular risk through in vitro and cohort studies.

bioRxiv · Dec 3, 2018 · PreprintGenomics

RL-SKAT: An exact and efficient score test for heritability and set tests

Regev Schweiger, Omer Weissbrod, Elior Rahmani, Martina Müller‐Nurasyid, Sonja Kunze, Christian Gieger, Mélanie Waldenberger, Saharon Rosset, Eran Halperin

RL-SKAT improves the accuracy of score tests for heritability and set-based genetic association by calculating exact p-values, avoiding the inflation or deflation of p-values seen in traditional methods.

Genetics · Oct 12, 2017Peer-reviewedGenetics