Author

Brooke L. Rhead

University of California, BerkeleyORCID 0000-0002-1839-4883Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 3 Genetic & Genomic Medicine· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Organism:human· 4 Assay:DNA methylation· 3 Research Focus:differential expression· 2 Research Focus:GWAS / association mapping· 2 Assay:GWAS summary statistics· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Lisa F. BarcellosiD· 3 shared Ahna Reza Girshick· 2 shared Asher K. Haug-Baltzell· 2 shared Catherine A. Ball· 2 shared Eleazar EskiniD· 2 shared Elior RahmaniiD· 2 shared Eran HalperiniD· 2 shared Eurie L. HongiD· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersGenomics

Lisa F. BarcellosORCID

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5 papers

Recent·Most cited

Mapping the human genetic architecture of COVID-19: an update

COVID-19 Host Genetics Initiative, Leadership, Gita A. Pathak, Juha M Karjalainen, Christine R. Stevens, Benjamin M. Neale, Mark J. Daly, Andrea Ganna, Writing group, Writing group lead, Shea J. Andrews, Masahiro Kanai, Mattia Cordioli, Analysis group, Manuscript analyses team lead, , David Morrison

This study updates the genetic architecture of COVID-19 by adding 11 new genome-wide significant loci through a large GWAS meta-analysis.

Nature · Aug 3, 2022Peer-reviewedGenetic & Genomic Medicine

Novel COVID-19 phenotype definitions reveal phenotypically distinct patterns of genetic association and protective effects

Genevieve H. L. Roberts, Raghavendran Partha, Brooke L. Rhead, Spencer C. Knight, Danny S. Park, Marie V. Coignet, Miao Zhang, Nathan Berkowitz, David A. Turissini, Michael Gaddis, Shannon McCurdy, Milos Pavlovic, Luong Ruiz, Chodon Sass, AncestryDNA Science Team, , Kristin A. Rand

The paper defines novel COVID-19 phenotypes and shows they reveal distinct genetic associations and protective effects compared to traditional definitions.

Nature Genetics · Apr 1, 2022Peer-reviewedGenetic & Genomic Medicine

Impact of genetic susceptibility to multiple sclerosis on the T cell epigenome: proximal and distal effects

Tina Roostaei, Hans‐Ulrich Klein, Yiyi Ma, Daniel Felsky, Pia Kivisäkk, Sarah M. Connor, Alexandra Kroshilina, Christina J. Yung, Belinda J. Kaskow, Xiaorong Shao, Brooke L. Rhead, José María Ordovás, Devin Absher, Donna K. Arnett, Jia Liu, , Philip L. De Jager

The paper identifies mQTL effects of MS susceptibility loci on DNA methylation in CD4+ T cells, revealing both cis and trans regulatory impacts.

Nature Communications · Dec 6, 2021Peer-reviewedGenomics

Calling differential DNA methylation at cell-type resolution: addressing misconceptions and best practices

Elior Rahmani, Brandon Jew, Regev Schweiger, Brooke L. Rhead, Lindsey A. Criswell, Lisa F. Barcellos, Eleazar Eskin, Saharon Rosset, Sriram Sankararaman, Eran Halperin

The paper benchmarks two methods for detecting cell-type-specific differential DNA methylation, finding TCA superior to CellDMC and discussing best practices for cell-type resolution analysis.

bioRxiv · Feb 14, 2021 · PreprintGenomics

Cell-type-specific resolution epigenetics without the need for cell sorting or single-cell biology

Elior Rahmani, Regev Schweiger, Brooke L. Rhead, Lindsey A. Criswell, Lisa F. Barcellos, Eleazar Eskin, Saharon Rosset, Sriram Sankararaman, Eran Halperin

The paper demonstrates a method to infer cell-type-specific DNA methylation from bulk data, revealing novel associations with leukocyte composition and rheumatoid arthritis.

Nature Communications · Jul 31, 2019Peer-reviewedGenomics