Matthew A. Kukurugya

The paper estimates ATP costs for mammalian cell growth and maintenance, showing that respiration alone cannot meet demands at fast growth rates, necessitating glycolytic ATP production.

The paper shows glycolysis produces ATP faster per gram of protein than respiration in E. coli, yeast, and mammalian cells, explaining the Warburg Effect as an optimization of energy production rate under proteome constraints.

This paper introduces a new framework to estimate in vivo protein turnover rates by addressing labeling identification and amino acid enrichment challenges, revealing differences in protein turnover between mice and naked mole-rats.