Pharmacology & ToxicologyPainPeer-reviewed
De novo nitric oxide synthesis drives tactile hypersensitivity induced by ATP-sensitive potassium channel opening in mice: Relevance to migraine and other headaches
Rikke Holm Rasmussen, Charlotte Ernstsen, Anja Holm…·Sarah Louise Christensen
This study shows that levcromakalim-induced tactile hypersensitivity in mice involves eNOS and peroxynitrite, not classical NO-sGC-cGMP signaling, suggesting nitrosative stress as a therapeutic target for migraine.
DOI 10.1097/j.pain.0000000000003955