De novo nitric oxide synthesis drives tactile hypersensitivity induced by ATP-sensitive potassium channel opening in mice: Relevance to migraine and other headaches
Rikke Holm Rasmussen, Charlotte Ernstsen, Anja Holm, Sabrina Prehn Lauritzen, Karina Obelitz‐Ryom, David M. Kristensen, Inger Jansen‐Olesen, Jes Olesen, Sarah Louise Christensen
This study shows that levcromakalim-induced tactile hypersensitivity in mice involves eNOS and peroxynitrite, not classical NO-sGC-cGMP signaling, suggesting nitrosative stress as a therapeutic target for migraine.
Pain · Apr 28, 2026Peer-reviewedPharmacology & Toxicology