Christophe Linhard

Identification of pleiotropic genes and biological mechanisms underlying the shared genetic component between asthma, neuropsychiatric disorders, and substance use behaviors

The paper identifies pleiotropic genes and mechanisms linking asthma, neuropsychiatric disorders, and substance use behaviors through multi-trait GWAS and single-cell transcriptomics.

Trait selection strategy in multi-trait GWAS: Boosting SNPs discoverability

This study evaluates trait selection strategies in multi-trait GWAS, finding that diverse trait sets improve variant detection compared to univariate screening and specific methods like JASS outperform others.

The murine Microenvironment Cell Population counter method to estimate abundance of tissue-infiltrating immune and stromal cell populations in murine samples using gene expression

The paper introduces mMCP-counter, a method to quantify immune and stromal cell populations in murine samples using gene expression, showing it outperforms existing methods and predicts treatment response.