Étienne Becht

The paper combines scRNA-seq and network propagation to refine gene signatures of TI-Tregs and Tex, revealing their biological processes and immunometabolic features.

This study shows that T lymphocytes from Crohn's disease patients impair intestinal epithelial integrity through increased cytotoxicity and altered immune responses in a 3D coculture model.

The paper introduces mMCP-counter, a method to quantify immune and stromal cell populations in murine samples using gene expression, showing it outperforms existing methods and predicts treatment response.

This paper provides an overview of single-cell RNA sequencing analysis using Bioconductor, highlighting its tools and methods for handling high-dimensional data.

The paper reproduces and extends findings from Ntranos et al., showing that MAST with Sidak p-value aggregation outperforms multivariate logistic regression on experimental scRNA-seq data.

The paper evaluates UMAP as an alternative to t-SNE for single-cell data, finding it faster, more consistent, and better at preserving cluster organization and continuums.

Hypergate optimizes flow-cytometry gating strategies for high yield and purity, outperforming human experts and machine learning models on public datasets.