Author

Wentao Yang

St. Jude Children's Research HospitalORCID 0000-0002-4496-0631Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Colton J. SmithiD· 2 shared Jun J.J. YangiD· 2 shared Mary V. RellingiD· 2 shared Nadezhda V. TerekhanovaiD· 2 shared Smita BhatiaiD· 2 shared Takaya MoriyamaiD· 2 shared Wenjian YangiD· 2 shared Xiaotu MaiD· 2 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenetics

Colton J. SmithORCID

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4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMay 6, 2026

Reactivation of a TAL1 progenitor cell enhancer region by non-coding somatic variants in T-lineage acute lymphoblastic leukemia

Nadezhda V. Terekhanova, Xiaolong Chen, Kin-Hoe Chow…·Jinghui Zhang

The paper identifies non-coding somatic variants in TAL1 regulatory regions that reactivate enhancers normally active in hematopoietic stem cells in T-lineage acute lymphoblastic leukemia.

DOI 10.64898/2026.05.03.722504

humanChIP-seq

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Cancer BiologyCancer CellPeer-reviewedMar 12, 2026

The landscape of structural variation in pediatric cancer

Robert Greenhalgh, Samuel W. Brady, Wentao Yang…·Jinghui Zhang

This study analyzes structural variants in 1,616 pediatric cancer genomes, revealing unique SV hotspots and patterns distinct from adult cancers.

5 citationstop 1%

humanwhole-genome sequencing

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GeneticsClinical Pharmacology & TherapeuticsPeer-reviewedOct 29, 2020

Effects of NT5C2 germline variants on 6-mecaptopurine metabolism in children with acute lymphoblastic leukemia

Chuang Jiang, Wenjian Yang, Takaya Moriyama…·Jun J.J. Yang

This study identifies NT5C2 germline variants affecting 6-MP metabolism in ALL patients, showing two independent variants influence TGN levels.

12 citations

humanbulk RNA-seq

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GenomicsbioRxivPreprintAug 20, 2019

Massive parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity

Chase C. Suiter, Takaya Moriyama, Kenneth A. Matreyek…·Jun J.J. Yang

The paper identifies 1,103 deleterious NUDT15 variants using functional assays, improving pharmacogenetics-guided thiopurine treatment by accurately predicting toxicity risk alleles.

2 citations

humanwhole-exome sequencing

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