Wenjian Yang

The paper maps human DNA replication origins using whole-genome sequencing data, identifying a 16 bp motif and periodicity, and links replication activity to gene expression and genetic variation.

This study investigates the impact of Indigenous American-like ancestry on acute lymphoblastic leukemia risk in Hispanic/Latino children, finding no global association but significant local haplotype effects.

This study identifies HKDC1 as a prometastatic enzyme in liver cancer that stabilizes β-catenin under hypoxia, enhancing cancer stemness.

BEAM integrates multiple omics profiles with multiple clinical outcomes using bootstrap resampling to identify significant associations, outperforming existing methods in simulations and a pediatric leukemia application.

The paper identifies noncoding genetic variants affecting chemotherapy response in childhood ALL by linking them to gene regulatory elements and showing functional impacts on drug sensitivity.

The paper maps chromatin accessibility in B-ALL subtypes using ATAC-seq, identifies TFs and genetic variants influencing chromatin architecture and gene regulation.

This study identifies NT5C2 germline variants affecting 6-MP metabolism in ALL patients, showing two independent variants influence TGN levels.

The paper identifies 1,103 deleterious NUDT15 variants using functional assays, improving pharmacogenetics-guided thiopurine treatment by accurately predicting toxicity risk alleles.

This paper introduces VAMP-seq, a method to assess the abundance of protein variants, and identifies pathogenic variants in PTEN and TPMT.