Nadezhda V. Terekhanova

The paper identifies non-coding somatic variants in TAL1 regulatory regions that reactivate enhancers normally active in hematopoietic stem cells in T-lineage acute lymphoblastic leukemia.

This study analyzes structural variants in 1,616 pediatric cancer genomes, revealing unique SV hotspots and patterns distinct from adult cancers.

The paper shows that mutant allele enrichment in bulk tumor RNA can be confounded by tumor purity and NMD, and demonstrates RNA-Seq can improve driver indel detection.

Seq2Karyotype (S2K) enables in-silico karyotyping from whole-genome sequencing data, revealing intratumoral heterogeneity and evolutionary trajectories in cancer samples.

This study uses linked-read sequencing to phase somatic mutations in multiple myeloma, extending haplotype blocks and revealing phasing patterns in key mutated genes.

The paper shows the Drosophila testis niche controls stem cell proliferation by repressing Hippo pathway genes without involving a binary fate decision between stemness and differentiation.