Proximity Proteome Analysis Reveals Novel TREM2 Interactors in the ER-Mitochondria Interface of Human Microglia
Chulhwan S. Kwak, Gina M. Finan, Yu Rim Park, Anjali Garg, Oscar Harari, Ji Young Mun, Hyun‐Woo Rhee, Taewan Kim
The paper identifies novel TREM2 interactors at the ER-mitochondria interface in human microglia using TurboID proximity labeling, revealing a role for TREM2 in MERC structural plasticity and potential involvement in Alzheimer's disease.
bioRxiv · Mar 21, 2023 · PreprintNeuroscience