Chulhwan S. Kwak

This study identifies MIRO1 as a context-specific modulator of BAX activity, showing it drives distinct cell death pathways in glioma cells and Parkinsonian neurons through different mechanisms.

MitoAtlas maps the sub-mitochondrial localization and topology of 861 proteins using SR-PL and AlphaFold, identifying new interactions and unannotated proteins.

The paper introduces optogenetic proximity labeling to map mitochondrial surface proteomes and ribosome pools, revealing Miro1's role in spatially organizing mitochondrial protein biogenesis.

The paper shows mitochondrial thermogenesis generates heat that triggers a nuclear heat-shock response in mammalian cells.

The paper identifies novel TREM2 interactors at the ER-mitochondria interface in human microglia using TurboID proximity labeling, revealing a role for TREM2 in MERC structural plasticity and potential involvement in Alzheimer's disease.