Paul Nardelli

Emulating the influence of exoskeleton stiffness on primary afferent feedback in rat isolated muscle-tendon unit

The paper investigates how exoskeleton stiffness affects muscle spindle firing in rats by applying controlled stretches with engineered springs and measuring biomechanical responses.

Oxaliplatin Induces Spontaneous Firing at Sensory Endings Across Touch and Proprioceptive Afferents

This study shows oxaliplatin induces spontaneous firing in sensory endings of touch and proprioceptive afferents in rats, which can occur without impairing overall sensory function.

Diverse and complex muscle spindle afferent firing properties emerge from multiscale muscle mechanics

This paper develops a biophysical model showing how muscle spindle afferent firing patterns emerge from muscle mechanics and neuromechanical interactions.

Cancer Exacerbates Chemotherapy Induced Sensory Neuropathy

The paper shows that chronic sensory neuropathy in rats results from non-linear interactions between cancer and chemotherapy, with Kv3.3 as a potential contributor.

Noncontractile tissue forces mask muscle fiber forces underlying muscle spindle Ia afferent firing rates in stretch of relaxed rat muscle

The paper shows that history-dependent muscle spindle Ia afferent firing rates in relaxed rat muscle mirror muscle fiber forces, which are masked by noncontractile tissue forces.