Kenneth S. Campbell

This study examines changes in calcium sensitivity and contractile properties of left atrial and ventricular myocardium in ischemic heart failure, finding increased calcium sensitivity and altered kinetics in the left atrium.

This study shows that cMLCK forms biomolecular condensates that enhance myosin motor phosphorylation in cardiac muscle cells, revealing a mechanism for regulating heart contractile function.

This paper uses simulations to show that concentric and eccentric cardiac growth are regulated by ATP homeostasis and titin-based stress, respectively, and can model growth patterns from both genetic and clinical causes.

This study investigates the molecular mechanism of cardiac myosin dysfunction caused by the A57D mutation in MLC1v using single-molecule analysis and computational modeling.

This study shows that phosphorylation of cardiac myosin regulatory light chain (RLC) is spatially controlled and modulates mechano-sensing in cardiac thick filaments.

This study identifies two distinct cardiac proteomic signatures in HFpEF linked to sex ratios, revealing molecular differences in structural machinery and cellular communication.

This paper develops a biophysical cross-bridge model to predict muscle short-range stiffness during movement, finding that cooperative myofilament activation is essential for accurate predictions.

The paper measures how mavacamten and deoxyATP affect the SRX/DRX ratio in porcine cardiac myofibrils using a fluorescence imaging approach.

This study investigates danicamtiv's effects on cardiac myosin mechanics and shows it enhances contraction by altering crossbridge kinetics and thin filament activation.

This study measures stress relaxation in myocardial tissue from failing and non-failing hearts, finding differences linked to fibrosis and fat accumulation.

This paper identifies a shear-dependent interaction between Protein S and von Willebrand Factor that reduces free PS anticoagulant activity and contributes to thrombotic risk in viral infections.

GelBox improves rigor and reproducibility in gel and immunoblot analysis by integrating image adjustments, background correction, band-fitting, and metadata association in a single open-source tool.

This study shows reduced mitochondrial supercomplex activity and abundance in pulmonary hypertension-induced right ventricular dysfunction in rats and humans.

This study shows that renal angiotensinogen in nonhuman primates is mainly derived from the liver, as evidenced by reduced renal AGT levels after liver-specific AGT inhibition.

This paper develops a biophysical model showing how muscle spindle afferent firing patterns emerge from muscle mechanics and neuromechanical interactions.