Author

Jonathan Richard Pilsner

Wayne State UniversityORCID 0000-0002-4541-6267Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:rat· 1

Frequent Co-Authors

Alexander SuvoroviD· 3 shared Olatunbosun K. ArowoloiD· 3 shared Jiahui ZhuiD· 2 shared Oladele A. OluwayioseiD· 2 shared Ekaterina Mironova· 1 shared Emily HouleiD· 1 shared Joseph P. McGaunniD· 1 shared Karolina NowakiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

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10 top collaborators · 30 mutual co-author links

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3 shared papersSystems Biology

Alexander SuvorovORCID

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3 papers

Recent·Most cited

Systems BiologyBiologyPeer-reviewedMar 21, 2026

Molecular Basis of Sperm Methylome Response to Aging and Stress

Olatunbosun K. Arowolo, Jiahui Zhu, Karolina Nowak…·Alexander Suvorov

The paper tests the SEV hypothesis by analyzing mouse and rat sperm methylome responses to age and stress, finding that methylation variation in VMRs increases with age, suggesting stress accelerates epigenetic aging.

2 citations

mouserat

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Molecular BiologybioRxivPreprintFeb 25, 2025

Mechanistic target of rapamycin/blood-testes barrier mechanism mediates acceleration of sperm epigenetic aging by environmental factors

Olatunbosun K. Arowolo, Oladele A. Oluwayiose, Jiahui Zhu…·Alexander Suvorov

The paper investigates how environmental factors like heat stress and cadmium affect sperm epigenetic aging through the mTOR/BTB mechanism in mice.

1 citation

mouseDNA methylation

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Developmental BiologyeLifePeer-reviewedJan 3, 2024

Mechanistic target of rapamycin (mTOR) pathway in Sertoli cells regulates age-dependent changes in sperm DNA methylation

Saira Amir, Olatunbosun K. Arowolo, Ekaterina Mironova…·Alexander Suvorov

This study shows that mTOR complex balance in Sertoli cells regulates sperm DNA methylation aging, with mTORC2 suppression accelerating aging and mTORC1 suppression causing rejuvenation.

12 citations

mouseDNA methylation

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