Author

Joseph P. McGaunn

Wayne State UniversityORCID 0000-0002-7754-8029Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Alexander SuvoroviD· 1 shared Ekaterina Mironova· 1 shared Jonathan Richard PilsneriD· 1 shared Oladele A. OluwayioseiD· 1 shared Olatunbosun K. ArowoloiD· 1 shared Oleg SergeyeviD· 1 shared Saira AmiriD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperDevelopmental Biology

Alexander SuvorovORCID

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1 paper

Recent·Most cited

Mechanistic target of rapamycin (mTOR) pathway in Sertoli cells regulates age-dependent changes in sperm DNA methylation

Saira Amir, Olatunbosun K. Arowolo, Ekaterina Mironova, Joseph P. McGaunn, Oladele A. Oluwayiose, Oleg Sergeyev, Jonathan Richard Pilsner, Alexander Suvorov

This study shows that mTOR complex balance in Sertoli cells regulates sperm DNA methylation aging, with mTORC2 suppression accelerating aging and mTORC1 suppression causing rejuvenation.

eLife · Jan 3, 2024Peer-reviewedDevelopmental Biology