Developmental BiologyeLifePeer-reviewed
Mechanistic target of rapamycin (mTOR) pathway in Sertoli cells regulates age-dependent changes in sperm DNA methylation
Saira Amir, Olatunbosun K. Arowolo, Ekaterina Mironova…·Alexander Suvorov
This study shows that mTOR complex balance in Sertoli cells regulates sperm DNA methylation aging, with mTORC2 suppression accelerating aging and mTORC1 suppression causing rejuvenation.
12 citations