Alexander Suvorov

This study tests small-molecule IGF1R inhibitors in mice to extend healthspan, finding improved physiological parameters and extended healthspan in one compound, but with toxicity and side effects.

The paper tests the SEV hypothesis by analyzing mouse and rat sperm methylome responses to age and stress, finding that methylation variation in VMRs increases with age, suggesting stress accelerates epigenetic aging.

The paper investigates how environmental factors like heat stress and cadmium affect sperm epigenetic aging through the mTOR/BTB mechanism in mice.

This study shows that mTOR complex balance in Sertoli cells regulates sperm DNA methylation aging, with mTORC2 suppression accelerating aging and mTORC1 suppression causing rejuvenation.