Sowmya Viswanathan

TGFB1-Engineered Induced Mesenchymal Stromal Cells Exhibit High Immunomodulatory Potency and Durably Reprogram Synovial Macrophages in Osteoarthritis

This study shows that TGFB1-engineered induced MSCs have distinct immunomodulatory effects compared to primary MSCs in an osteoarthritis model.

Human knee osteoarthritis patient-specific cartilage-on-a-chip model captures donor differences to stressors and treatments

This paper develops a patient-derived cartilage-on-a-chip model for KOA that captures donor differences in response to stressors and treatments.

Mesenchymal Stromal Cells Immunosuppress Osteoarthritis Synovial Fluid Modulated Monocytes via IL-6 and CCL2

The paper shows that MSCs reduce dysfunction in KOA synovial fluid-modulated monocytes via IL-6 and CCL2, restoring phagocytosis and reducing inflammation.

Joint tissue explant model using psoriatic arthritis synovial fluid as a tool to capture patient-specific responses to treatments

This study develops a patient-specific explant model using psoriatic arthritis synovial fluid to evaluate treatment responses in PsA.

Combined computational and experimental analysis confirm donor-dependent optimization of critical processing parameters for improving mesenchymal stromal cell potency and expansion attributes

Responders vs. non-responders to mesenchymal stromal cells in knee osteoarthritis patients: mechanistic correlates of donor cell attributes and putative patient features

The paper identifies donor cell attributes and patient features that correlate with response to mesenchymal stromal cell (MSC) injections in knee osteoarthritis patients.