Rajiv Gandhi

This paper develops a patient-derived cartilage-on-a-chip model for KOA that captures donor differences in response to stressors and treatments.

The paper shows that MSCs reduce dysfunction in KOA synovial fluid-modulated monocytes via IL-6 and CCL2, restoring phagocytosis and reducing inflammation.

This study develops a patient-specific explant model using psoriatic arthritis synovial fluid to evaluate treatment responses in PsA.

This study identifies EphB4 as a critical mediator of pulmonary fibrosis through genetic and pharmacological approaches, showing reduced ECM gene expression and fibrotic pathology.

The paper identifies donor cell attributes and patient features that correlate with response to mesenchymal stromal cell (MSC) injections in knee osteoarthritis patients.

This study creates a cellular atlas of synovium in human and mouse knee osteoarthritis, identifying BHLHE40 as a key regulator of fibroblast activation and fibrosis.

This study uses multi-omic approaches to analyze cellular and transcriptomic diversity in infrapatellar fat pad during knee osteoarthritis, identifying fibroblasts as key contributors to disease-related differences.