Guruprasad Kalthur

This study develops 3D ovarian scaffolds using decellularized extracellular matrix and mechanically tuned hydrogels to improve in vitro ovarian models.

The paper identifies a rare multipotent epithelial cell in the fallopian tube as a potential cell-of-origin for high-grade serous ovarian cancer using multi-omic profiling and organoid models.

This study identifies cKIT as a key mediator of oxidative signaling in human mammary luminal progenitor cells and links its activation to poor outcomes in basal-like breast cancers.

The paper shows that asexual haploid blastocyst fitness varies across mouse strains, with selectively-inbred mice showing higher success rates in generating haploid blastocysts compared to outbred mice.

The paper analyzes the impact of puberty blockers on testicular cell states and function using single-cell RNA sequencing and clinical data from PB-treated children.