Cancer BiologybioRxivPreprint
CASTOR1: A Novel Tumor Suppressor Linking mTORC1 and KRAS Pathways in Tumorigenesis and Resistance to KRAS-Targeted Therapies in Non-Small Cell Lung Cancer
Xian Wang, Ling Ding, Shenyu Sun…·Shou‐Jiang Gao
This study identifies CASTOR1 as a tumor suppressor in NSCLC that modulates mTORC1 and KRAS signaling, and shows that its loss promotes tumorigenesis and resistance to KRAS inhibitors.
2 citations