Author

Shenyu Sun

University of Pittsburgh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

Ling DingiD· 2 shared Shou‐Jiang GaoiD· 2 shared Xian WangiD· 2 shared Yufei HuangiD· 2 shared Arjun PennathuriD· 1 shared Karla PaniaguaiD· 1 shared Luping CheniD· 1 shared Man-Tzu Wang· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

Ling DingORCID

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2 papers

Recent·Most cited

KSHV Reprograms Host RNA Splicing via FAM50A to Activate STAT3 and Drive Oncogenic Cellular Transformation

Shenyu Sun, Karla Paniagua, Ling Ding, Xian Wang, Yufei Huang, Mario A. Flores, Shou‐Jiang Gao

This study identifies FAM50A-mediated splicing reprogramming by KSHV as a mechanism to activate STAT3 and drive oncogenic transformation in mesenchymal stem cells.

mBio · Jun 12, 2025Peer-reviewedCancer Biology

CASTOR1: A Novel Tumor Suppressor Linking mTORC1 and KRAS Pathways in Tumorigenesis and Resistance to KRAS-Targeted Therapies in Non-Small Cell Lung Cancer

Xian Wang, Ling Ding, Shenyu Sun, Suet Kee Loo, Luping Chen, Tingting Li, Man-Tzu Wang, Arjun Pennathur, Yufei Huang, Shou‐Jiang Gao

This study identifies CASTOR1 as a tumor suppressor in NSCLC that modulates mTORC1 and KRAS signaling, and shows that its loss promotes tumorigenesis and resistance to KRAS inhibitors.

bioRxiv · Apr 23, 2025 · PreprintCancer Biology