Estradiol mediates stress-susceptibility in the male brain
Polymnia Georgiou, Abagail F. Postle, Ta-Chung M. Mou, Liam E. Potter, Xiaoxian An, Panos Zanos, Michael S. Patton, Katherine J. Pultorak, Sarah M. Clark, Vien Ngyuyen, Chris F. Powels, Katalin Prókai-Tátrai, Antonis Kirmizis, Istvan J. Merchenthaler, László Prókai, , Todd D. Gould
The paper shows that estradiol, not testosterone, mediates stress susceptibility in male mice by modulating specific neural circuits, and brain delivery of estradiol prevents depression-like behaviors.
Molecular Psychiatry · Apr 23, 2025Peer-reviewedNeuroscience