Panos Zanos

Ethanol withdrawal induces temporally distinct alterations in oxytocinergic, opioidergic, glutamatergic and neuroimmune systems associated with recognition memory deficits

This study examines time-dependent changes in receptor systems during ethanol withdrawal and links mGlu5R alterations to memory deficits.

VirTarget: Virus-Informed Pharmacogenomics Framework Identifies Immunotherapies That Mitigate Epstein-Barr Virus-Driven Dysregulation in Multiple Sclerosis

VirTarget evaluates MS immunotherapies' effects on EBV-driven dysregulation and host genetics, identifying therapies that reverse or reinforce EBV-MS interactions.

Selective transcriptomic recovery by (2R,6R)-hydroxynorketamine in opioid-abstinent mice: Machine learning identifies predictive biomarkers

This study uses machine learning to identify predictive biomarkers of (2R,6R)-HNK treatment response in opioid-abstinent mice, revealing gene expression changes and context-dependent therapeutic effects.

Estradiol mediates stress-susceptibility in the male brain

The paper shows that estradiol, not testosterone, mediates stress susceptibility in male mice by modulating specific neural circuits, and brain delivery of estradiol prevents depression-like behaviors.

Metformin Shows Greater Potential Than Semaglutide in Reducing Alzheimer's Risk in Diabetes Type II via Dual Actions: Tackling Disease Pathways and Environmental Herpesvirus Triggers

This study compares Metformin and Semaglutide for Alzheimer's risk reduction in Type II Diabetes using network pharmacology, MR, and transcriptomics, finding Metformin more effective through dual mechanisms.

Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions.

The paper investigates how ketamine's metabolism via hepatic CYP450 enzymes affects its antidepressant effects, finding that (6)-HNKs mediate sustained antidepressant actions.

Network-Based Analysis Identifies Targetable Pathways in Comorbid Type II Diabetes and Neuropsychiatric Disorders

The paper identifies shared molecular pathways between Type II Diabetes and neuropsychiatric disorders using a network-based approach, highlighting potential therapeutic targets.

From Viral Infections to Alzheimer's Disease: Unveiling the Mechanistic Links Through Systems Bioinformatics

This study identifies viral-mediated mechanisms linking specific viruses to Alzheimer's Disease through systems bioinformatics analysis of virus-host protein interactions.

(2R,6R)-hydroxynorketamine facilitates extinction and prevents emotional impairment and stress-induced reinstatement in morphine abstinent mice

This paper demonstrates that (2R,6R)-hydroxynorketamine reverses maladaptive behaviors and prevents relapse in morphine-abstinent mice by enhancing BDNF and GluN2A signaling.

Experimenter sex modulates mouse biobehavioural and pharmacological responses

This study shows that the sex of human experimenters affects mouse behaviors, stress responses, and drug responses like ketamine, mediated by CRF neurons.