Generation and characterization of Ccdc28b mutant mice links the Bardet-Biedl associated gene with social behavioral phenotypes
Matías Fabregat, Sofía Niño, Sabrina Pose, Magdalena Cárdenas-Rodríguez, Corrine Smolen, Mariana Bresque, Karina Hernández, Victoria Prieto-Echagüe, Geraldine Schlapp, Martina Crispo, Patricia Lagos, Natalia Lago, Santhosh Girirajan, Carlos Escande, Florencia Irigoı́n, José Luis Badano
This paper generates Ccdc28b mutant mice and finds they exhibit social behavioral defects and autism-like features, suggesting a link between CCDC28B and autism spectrum disorder beyond its role as a modifier of Bardet-Biedl syndrome.
bioRxiv · Oct 21, 2021 · PreprintGenetics