Hugo Bisio

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life

The paper identifies that giant DNA viruses encode a functional IF4F translation initiation complex, enabling viral protein synthesis and challenging the distinction between cellular and acellular biology.

Elucidating the interaction network of one of the largest icosahedral capsids in the virosphere

The paper investigates the interaction network of mimivirus, revealing distinct protein modules and conserved assembly nodes in its icosahedral capsid.

Melbournevirus encodes a shorter H2B-H2A doublet histone variant that forms structurally distinct nucleosome structures.

The paper identifies a unique H2B-H2A histone variant in Melbournevirus that forms structurally distinct nucleosomes with reduced DNA binding capacity.

Nucleocytoviricota viral factories are transient organelles made by liquid-liquid phase separation

The paper shows that Nucleocytoviricota viral factories are transient organelles formed by liquid-liquid phase separation, using scaffold proteins and client proteins.