Yohann Couté

This study identifies VASH1 phosphorylation by PRKG1 as a mechanism regulating tubulin detyrosination in DRG neurons through CNP signaling.

This study investigates the role of DTH1 in remodeling lipid and protein environments of lipid droplets during nutrient recovery in Chlamydomonas, revealing its impact on lipid degradation and organelle communication.

This study identifies HCK signaling as a driver of long-distance ECM degradation in macrophages through endo-exocytosis coupling involving MMPs and cathepsins.

This study identifies ACSF3 as a diurnal regulator of lysine-malonylation and hepatic metabolism, showing its rhythmic expression and role in glycogen storage, lipogenesis, and triglyceride synthesis.

This study shows mechanical compression remodels the nucleolus, reduces rDNA transcription, and identifies nucleolin as a mediator of this response through biophysical and epigenetic mechanisms.

This study identifies RNAseT2 as a macrophage-derived factor that promotes muscle stem cell fusion through SLK/N-WASP/actin bundling in mouse and zebrafish.

This study develops a decellularized adipose tissue-derived hydrogel (atdECM) that supports pancreatic organoid growth with improved transcriptional profiles compared to Matrigel.

The paper develops an improved method to capture ribosome-associated proteins and shows viral infections remodel these proteins in a virus-specific manner, with functional implications for viral propagation.

This study identifies a type I interferon signaling signature in XPC-deficient keratinocytes, linking UVB exposure to JAK/STAT pathway dysregulation and hypersensitivity.

The paper uses proteomic profiling to identify DNAJC9 and MCM2 as key histone chaperones involved in chromatin repair during UV damage response in human cells.

This study shows that Lactobacillus helveticus VEL12193 promotes autophagy in vitro and in vivo through membrane vesicles, with potential applications for healthy aging.

This study identifies KDM7B as a demethylase that regulates RNF113A, affecting DNA repair and chemoresistance in small cell lung cancer.

This study investigates the RPL5-I60V mutation in T-ALL, showing it increases translation and alters drug sensitivity in leukemia cells.

The paper investigates the interaction network of mimivirus, revealing distinct protein modules and conserved assembly nodes in its icosahedral capsid.

This study identifies 57 uranyl-binding proteins in Arabidopsis thaliana cells, with GRP7 showing specific U(VI) binding and interference with RNA binding, suggesting a role in uranium toxicity.

This study identifies CARM1-mediated methylation of ALIX as critical for its interactions with SH3-domain proteins during cytokinesis.

This paper develops an optimized dCas9-based CAPTURE method for studying DNA-protein interactions in the nematode Meloidogyne incognita, identifying chromatin-associated proteins involved in effector gene regulation.

This study shows NLRP3 promotes homologous recombination by interacting with REV7, enhancing DNA repair and affecting PARP inhibitor sensitivity.

This study characterizes ribosome heterogeneity in adult mouse organs using proteomics, revealing tissue-specific ribosomal protein (RP) signatures and translational regulation of RP expression.

This study identifies Rsc1-BD2 as a DNA-binding module in yeast RSC that mediates nucleosome remodeling at polyA-rich promoters.

The paper identifies a blue light signaling pathway in green algae that inhibits starch accumulation via PMSK1 dephosphorylation and GAP1 repression.

This study identifies LHL4 as a photoprotective protein in Chlamydomonas reinhardtii that prevents photodamage to photosystem II by binding its monomeric form and reducing singlet oxygen accumulation.

This paper identifies ABHD1 as a lysolipid lipase involved in lipid droplet formation through enzymatic and structural actions on the LD surface in Chlamydomonas.

This study reveals the structure and interactions of the plastid-encoded RNA polymerase (PEP) in Sinapis alba, showing its role in coordinating plastid transcription with light signaling and photosynthetic apparatus assembly.

The paper shows that Nucleocytoviricota viral factories are transient organelles formed by liquid-liquid phase separation, using scaffold proteins and client proteins.

This study identifies AtVPS13M1 as a lipid transporter in Arabidopsis thaliana that affects phospholipid degradation during phosphate starvation and localizes to mitochondria.

This study identifies phosphorylation changes in host proteins induced by HBV infection in primary human hepatocytes, revealing an intrinsic anti-viral response involving DNA repair and RNA-binding proteins.

The paper identifies a novel tardigrade-specific DNA binding protein, TDR1, that enhances resistance to ionizing radiation in human cells.

This study shows that NME1/2 regulate liver response to high-fat diet by repressing de novo lipogenesis and activating protective gene expression through histone acetylation.

This study identifies two distinct SIN3 complexes in C. elegans that regulate germline gene expression and fertility, revealing their role in X-linked gene silencing.