Amy S.Y. Lee

Ribosome remodeling drives translation adaptation during viral infection and cellular stress

The paper shows that ribosome remodeling enables enhanced viral protein synthesis during infection and cellular stress by altering ribosome composition and structure.

Evolution of a core ribosomal innovation in octopus

The paper identifies a unique structural break in octopus ribosomal RNA that enhances translation fidelity and supports proteomic stability through RNA editing.

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life

The paper identifies that giant DNA viruses encode a functional IF4F translation initiation complex, enabling viral protein synthesis and challenging the distinction between cellular and acellular biology.

Nuclease-NTPase systems use shared molecular features to controlbacterial anti-phage defense

The paper analyzes 16 nuclease-NTPase systems to identify shared features controlling bacterial anti-phage defense, revealing universal protein complex formation and broad nucleic acid degradation capabilities.

Repression of ferritin light chain translation by human eIF3

The paper identifies eIF3 as a repressor of FTL mRNA translation and shows that SNPs causing hyperferritinemia disrupt this repression.