A Multidimensional Analysis of the Bimodal Piperaquine Response in Plasmodium falciparum
John Kane, Aubrey R. Schall, Lisa A. Checkley, Douglas A. Shoue, Sydney M. Gavula, Caroline Thomas, Xue Li, Ian H. Cheeseman, Ashley M. Vaughan, Timothy J. C. Anderson, Manuel Llinás, Paul D. Roepe, Michael T. Ferdig
The paper investigates the bimodal piperaquine response in Plasmodium falciparum by analyzing metabolic, transcriptional, and molecular dynamics data to identify the role of plasmepsin II/III copy number and pfcrt mutations.
bioRxiv · Jul 7, 2026 · PreprintMolecular Biology