Manuel Llinás

The paper investigates the bimodal piperaquine response in Plasmodium falciparum by analyzing metabolic, transcriptional, and molecular dynamics data to identify the role of plasmepsin II/III copy number and pfcrt mutations.

This study identifies PF3D7_0707400 as an essential ATAD3A ortholog in Plasmodium falciparum, showing its role in mitochondrial processes and parasite survival.

This study identifies PfMD3 as an RNA-binding protein that regulates male gamete fertility by impacting translation in Plasmodium falciparum.

This study identifies and characterizes long non-coding RNAs in Plasmodium falciparum across asexual and gametocyte stages using long-read sequencing and single-cell transcriptomics.

This study identifies a novel K13 double mutation conferring resistance to ozonide antimalarials in Plasmodium falciparum parasites with existing artemisinin resistance.

This study identifies a valine-to-leucine mutation in AP2-G that disrupts DNA binding and sexual differentiation in Plasmodium falciparum, revealing GDV1's role in ap2-g activation.

This study examines chromatin state dynamics and TF binding in Plasmodium falciparum during its intraerythrocytic development cycle, revealing stable and dynamic chromatin states linked to gene regulation.

The paper uses metabolomics to show that antimalarial drug combinations have unique metabolic effects compared to individual drugs, supporting their use in treatment.

This study investigates rRNA dynamics in Plasmodium falciparum during gametocytogenesis, revealing specific degradation patterns and shifts in rRNA types across developmental stages.

This study uses CRISPR/Cas9 to knockout plasmepsin II and III in Cambodian malaria parasites, showing increased sensitivity to piperaquine and linking plasmepsin gene copy numbers to PPQ resistance.

This study shows that disrupting the hexosamine biosynthetic pathway in Plasmodium falciparum blocks GPI production, arrests parasite growth, and prevents egress from host cells.

The paper identifies multiple redundant carboxylic acid transporters in Plasmodium falciparum that support mitochondrial metabolism, revealing metabolic flexibility in the parasite.

The paper determines the crystal structure of the ACDC domain from ApiAP2 proteins in malaria parasites and identifies a potential inhibitor targeting this domain.

The paper investigates how DNA sequence and chromatin context influence transcription factor binding in Plasmodium falciparum, showing that both factors contribute to differential binding site selection.

The paper identifies antimalarial compounds that inhibit ApiAP2 proteins in Plasmodium falciparum by screening small molecules against the AP2-EXP domain and validating their effects on parasite gene regulation and growth.

This study develops DAFT-seq, an amplification-free RNA-seq protocol for P. falciparum, refining the transcriptome by improving coverage of AT-rich regions and identifying new transcriptional features.

The paper shows PfAP2-G activates gametocyte genes and also promotes red blood cell invasion genes, linking sexual differentiation to invasion in malaria parasites.