Douglas A. Shoue

The paper functionally validates the Plasmodium falciparum K13 C580Y mutation in Ethiopian isolates, showing it confers artemisinin tolerance.

The paper investigates the bimodal piperaquine response in Plasmodium falciparum by analyzing metabolic, transcriptional, and molecular dynamics data to identify the role of plasmepsin II/III copy number and pfcrt mutations.

This paper develops and validates a qPCR-based assay to measure growth, resistance, and recovery of Plasmodium falciparum after artemisinin treatment, showing distinct phenotypes with independent genetic determinants.

The paper evaluates the impact of K13 mutations on artemisinin resistance and parasite fitness in Bangladeshi Plasmodium falciparum isolates, finding that R561H confers extreme resistance and fitness advantages.

This study uses a genetic cross of Plasmodium falciparum isolates to analyze the roles of pfcrt and pm2/3 in piperaquine resistance and fitness traits.

The paper sequences and annotates the genomes of two sand fly species, identifying genes related to vector biology and population structure to aid in leishmaniasis control.

This study identifies pfaat1 as a key gene in chloroquine resistance evolution in malaria parasites, showing it modulates resistance and fitness through amino acid transport.

This study optimizes bulk segregant analysis for identifying drug resistance loci in Plasmodium falciparum using genetic crosses in humanized mice, confirming the kelch13 locus and demonstrating the utility of cryopreserved pools.

The paper analyzes genetic variability and immune response potential of salivary proteins in Phlebotomus papatasi sand flies from Egypt and Jordan.

The paper reports two new genetic crosses of Plasmodium falciparum in humanized mice, showing significant variation in marker segregation and demonstrating improved power for genetic mapping of malaria traits.