Plasmacytoid dendritic cells in the intestine preferentially produce interferon lambda at homeostasis contributing to tonic localized innate immune responses
David A. Constant, Jacob A. Van Winkle, Philip A Norwood, Gargi Mishra, Kimberly A. Meyer, Margaret E Laney, Shelby R. Madden, Alec M. Griffith, Patrick Fernandes Rodrigues, Ram Savan, Timothy J. Nice
This study identifies intestinal plasmacytoid dendritic cells (pDC) as a major source of homeostatic IFN-λ and shows TGF-β regulates their IFN production.
bioRxiv · Aug 25, 2025 · PreprintImmunology