Ram Savan

This study identifies IRF5 as a critical driver of iHPC differentiation and MAS pathogenesis, showing it can be targeted pharmacologically.

This paper identifies lineage-specific chromatin accessibility differences at IFN gene loci in pDCs and epithelial cells, revealing ETS-IRF composite elements as key regulators of divergent interferon responses.

This study identifies intestinal plasmacytoid dendritic cells (pDC) as a major source of homeostatic IFN-λ and shows TGF-β regulates their IFN production.

The paper identifies lncRNAs that influence VEEV replication in mouse astrocytes, showing that suppressing Snhg15 increases viral replication and affects antiviral gene expression.

The paper predicts 3D structures of viral-host protein interactions and identifies evolutionary patterns and functional mechanisms underlying viral pathogenesis.

A small increase in NOD1 expression leads to cancer-promoting changes in cell state by promoting persistent inflammation and oncogene expression.