Alec M. Griffith

A critical signaling role for diacylglycerol in phagocytosis of M. tuberculosis

This study identifies diacylglycerol (DAG) as critical for phagocytosis of M. tuberculosis, showing that DAG disruption reduces uptake without affecting receptor trafficking or cargo binding.

Plasmacytoid dendritic cells in the intestine preferentially produce interferon lambda at homeostasis contributing to tonic localized innate immune responses

This study identifies intestinal plasmacytoid dendritic cells (pDC) as a major source of homeostatic IFN-λ and shows TGF-β regulates their IFN production.

Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis

The paper identifies activated lymphocyte phenotypes in individuals at risk for rheumatoid arthritis using mass cytometry and develops an immunophenotype score to distinguish these individuals from controls.