Cancer BiologyMolecular Biology ReportsPeer-reviewed
Spheroid architecture strongly induces miR-221/222 expression and promotes oxidative phosphorylation and survival of mobile tumor cells through a mechanism that includes restriction of miR-9 expression
Avery S. Ward, Cody N. Hall, Maya O. Tree, D. Stave Kohtz
This study shows that spheroid architecture increases miR-221/222 expression and OXPHOS activity in ovarian cancer cells, enhancing their survival in nutrient-poor environments.