Bolni Marius Nagalo

Pancreatic tumor microenvironment reprogramming via alloantigen-expressing virotherapy elicits tumor rejection and improves immunotherapy response

Oncolytic virus-based delivery of an alloantigen improves antitumor immunity and synergizes with immune checkpoint inhibitors in pancreatic cancer.

CMTM6-Silencing Microbial Immunotherapy Reprograms PDAC Tumors and Restores T-cell Function

This paper develops iSTORM, a Salmonella-based immunotherapy that silences CMTM6 in PDAC tumors, enhancing T-cell function and tumor control while maintaining safety.

Repeat Systemic Delivery of Cross-Neutralization Resistant Synthetic Vesiculoviruses Immunomodulates the Tumor Microenvironment

A glycoprotein-engineered vesiculovirus platform circumvents neutralizing antibodies, enabling repeat intravenous dosing and sustained anti-tumor immunity in preclinical models.

Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model

This study evaluates the anti-breast cancer activity of monensin and its analogs in organoid models, finding they reduce stem-like cell proliferation and dysregulate stemness markers.

The Structure of ChAdOx1/AZD-1222 Reveals Interactions with CAR and PF4 with Implications for Vaccine-induced Immune Thrombotic Thrombocytopenia

The paper determines the structure of the ChAdOx1 adenovirus vector and identifies interactions with CAR and PF4, proposing a mechanism for vaccine-induced immune thrombotic thrombocytopenia.