Abhishek Singharoy

Ultrafast X-Rays Capture Retinal Traversing Conical Intersection in Rhodopsin

This study uses ultrafast X-ray scattering to observe retinal cis-trans isomerization in rhodopsin, revealing how cofactor dynamics drive activation without crystal lattice constraints.

Transient protein structure guides surface diffusion pathways for electron transport in membrane supercomplexes

This study uses multiscale modeling and cryo-EM to show that transient protein structures guide electron transfer in mitochondrial supercomplexes, improving energy conversion efficiency by 30%.

Prebiotically Plausible Peptides can Self-assemble into beta-rich Assemblies

This study shows random 25-mer peptides with a prebiotically plausible amino acid alphabet can self-assemble into thermostable beta-rich nanostructures.

A membrane-associated conveyor belt controls the rotational direction of the bacterial type 9 secretion system

The paper identifies how the C-terminus of GldJ controls the rotational direction of the T9SS in Flavobacterium johnsoniae, revealing a mechanism for directional gliding motility.

Finding the E-Channel Proton Loading Sites by Calculating the Ensemble of Protonation Microstates

The paper identifies proton loading sites in Complex I by analyzing protonation microstates using MCCE and Molecular Dynamics simulations.

Upregulation of the Proto-Oncogene Src Kinase in Alzheimer's Disease: From Molecular Interactions to Therapeutic Potential

This study shows Src kinase is upregulated and phosphorylated in Alzheimer's disease, interacts with Tau, and may be a therapeutic target.

Functional Organization of Glycolytic Metabolon on Mitochondria

This study identifies OGT-mediated O-GlcNAcylation of HK1 as a mechanism regulating glycolytic metabolon assembly on mitochondria, enhancing ATP production and synaptic function.

The Structure of ChAdOx1/AZD-1222 Reveals Interactions with CAR and PF4 with Implications for Vaccine-induced Immune Thrombotic Thrombocytopenia

The paper determines the structure of the ChAdOx1 adenovirus vector and identifies interactions with CAR and PF4, proposing a mechanism for vaccine-induced immune thrombotic thrombocytopenia.