Chronic striatal cholinergic interneuron excitation induces clinically-relevant dystonic behavior in mice
Kat Gemperli, Xinguo Lu, Keerthana Chintalapati, Alyssa Rust, Rishabh Bajpai, Nathan Suh, Joanna Blackburn, Rose Gelineau‐Morel, Michael C. Kruer, Dararat Mingbundersuk, Jennifer A. O’Malley, Laura S. Tochen, Jeff L. Waugh, Steve W. Wu, Timothy J. Feyma, , Bhooma R. Aravamuthan
Chronic excitation of striatal cholinergic interneurons in mice induces clinically-relevant dystonic leg adduction variability, supporting their role in dystonia and suggesting therapeutic targets.
bioRxiv · Jul 19, 2023 · PreprintNeuroscience