Xinguo Lu

The paper investigates the role of δ subunit-containing GABA-A receptors on parvalbumin positive neurons in shaping electrocortical activity during sleep states, finding altered EEG patterns in their absence.

This study uses 3D direct neuronal reprogramming of AD patient fibroblasts to recapitulate AD neuropathology, showing A{beta} deposition, tauopathy, and neuronal death, and identifies potential therapeutic targets.

This study shows that δ-containing GABAA receptors in PV interneurons regulate their excitability and inhibit pyramidal neurons in the mPFC, affecting network dynamics.

Chronic excitation of striatal cholinergic interneurons in mice induces clinically-relevant dystonic leg adduction variability, supporting their role in dystonia and suggesting therapeutic targets.