Adam C. Weiner

Using image classifiers to predict CMT2A disease-relevant mitochondrial motility phenotypes in iPSC motor neurons

This paper develops a vision transformer framework to classify CMT2A disease phenotypes in iPSC motor neurons using kymographs, showing improved accuracy over traditional metrics.

Ongoing genome doubling promotes evolvability and immune dysregulation in ovarian cancer

This study shows that ongoing whole-genome doubling in ovarian cancer promotes cell diversity and immune dysregulation through chromosomal instability and quiescent states.

Live-cell analyses with unsegmented images to study cancer cell response to modified T cell therapy

This paper introduces a segmentation-free method to analyze live-cell imaging data of T cell-cancer cell interactions, revealing how T cell modifications affect aggregate formation dynamics.

CINner: modeling and simulation of chromosomal instability in cancer at single-cell resolution

CINner models chromosomal instability in cancer, showing how selection parameters and WGD influence tumor progression and heterogeneity.

Luminal breast epithelial cells from wildtype and BRCA mutation carriers harbor copy number alterations commonly associated with breast cancer

The paper analyzes copy number alterations in breast epithelial cells from BRCA mutation carriers and wildtype individuals, finding lineage-specific CNAs that mirror cancer genomes.