Amir Giladi

NOTCH-driven oscillations control cell fate decisions during intestinal homeostasis

The paper shows that NOTCH-driven Hes1 oscillations with different periods control cell fate decisions in intestinal stem cells, influencing secretory and absorptive lineage commitment.

Random mtDNA mutagenesis maps genotype-phenotype associations across metabolic contexts and lineages

The paper introduces mtDIVE, a random mtDNA mutagenesis platform, to study genotype-phenotype associations in metabolic contexts and lineages, revealing lineage-specific effects and mutation-specific impacts.

A Dual-Pathway Wnt-IL-13 Fusion Protein Enhances Human Intestinal Regeneration Through Tuft Cell Activation

This paper develops a Wnt-IL-13 fusion protein that activates tuft cells to enhance intestinal regeneration in human organoids.

TREM2 macrophages are associated with enhanced response to PD-1 blockade in human hepatocellular carcinoma

The paper identifies TREM2-expressing macrophages as predictors of response to PD-1 blockade in HCC patients using clinical and spatial transcriptomic data.

T cell-derived IFN-γ Suppresses T Follicular Helper Cell Differentiation and Antibody Responses

The paper shows that T cell-derived IFN-γ suppresses TFH differentiation and antibody responses by acting through dendritic cells, not directly on CD4+ T cells.

Tuft cells act as regenerative stem cells in the human intestine

The paper identifies four human tuft cell states, showing they function as radiation-resistant stem cells capable of regenerating the intestinal epithelium.

Single-cell atlas of mouse limb development reveals a complex spatiotemporal dynamics of skeleton formation

The paper uses single-cell RNA sequencing to study mouse limb development, identifying progenitor states and their differentiation into skeletal elements in a spatiotemporal pattern.

MetaCell: analysis of single cell RNA-seq data using k-NN graph partitions

MetaCell partitions scRNA-seq data into homogeneous metacells to address sparsity, enabling clustering and gene expression analysis without enforcing global structure.