Bimal Jana

Clinical, in vitro, and in vivo evidence of WAPL as a novel cohesinopathy gene and phenotypic driver of 10q22.3q23.2 genomic disorder

The paper identifies WAPL as a novel cohesinopathy gene and driver of a genomic disorder, showing its role in developmental delay and other anomalies through clinical, in vitro, and in vivo analyses.

Dual CRISPRi-Seq for genome-wide genetic interaction studies identifies key genes involved in the pneumococcal cell cycle

This study uses dual CRISPRi-Seq to identify genetic interactions in Streptococcus pneumoniae, revealing key genes in the cell cycle and new interactions in essential processes.

In vivo tests of the E. coli TonB system working model:interaction of ExbB with unknown proteins, identification of TonB-ExbD transmembrane heterodimers and PMF-dependent ExbD structures.

The paper validates aspects of the TonB system working model through in vivo experiments, identifying new ExbB-interacting proteins and PMF-dependent ExbD conformational changes.

CRISPRi-TnSeq: A genome-wide high-throughput tool for bacterial essential-nonessential genetic interaction mapping

CRISPRi-TnSeq maps genetic interactions between essential and nonessential genes in bacteria, identifying 1,334 interactions and revealing pathway dependencies and functional relationships.

Studies on the Escherichia coli ExbD Transmembrane Domain, Residue L132, and an Inhibitory Cyclic Peptide.

This paper investigates the Escherichia coli ExbD transmembrane domain, identifies key residues for TonB system activity, and demonstrates that a cyclic peptide can inhibit ExbD-TonB interaction, suggesting a potential antimicrobial strategy.