Clément Gallay

A bacterial cell wall repair and modification system to resist host antibacterial factors

This paper identifies the pneumococcal S protein as essential for resisting host antimicrobials by coordinating cell wall modification and repair through interactions with PBP1a and PgdA.

Strain-resolved CRISPRi-Seq reveals conserved antibiotic vulnerabilities in Staphylococcus aureus

The paper uses CRISPRi-Seq to identify conserved antibiotic vulnerabilities in S. aureus strains, revealing gene targets for antimicrobial therapies.

The ClpX chaperone and a hypermorphic FtsA variant with impaired self-interaction are mutually compensatory for coordinating Staphylococcus aureus cell division

The paper shows that ClpX chaperone and a hypermorphic FtsA variant compensate for each other in Staphylococcus aureus cell division by modulating FtsA interactions and septum synthesis.

CRISPRi-TnSeq: A genome-wide high-throughput tool for bacterial essential-nonessential genetic interaction mapping

CRISPRi-TnSeq maps genetic interactions between essential and nonessential genes in bacteria, identifying 1,334 interactions and revealing pathway dependencies and functional relationships.