Mammalian UPF3A and UPF3B activate NMD independently of their EJC binding
Zhongxia Yi, René M. Arvola, Sean Myers, Corinne Dilsavor, Rabab Abu Alhasan, Bayley N Carter, Robert D. Patton, Ralf A. Bundschuh, Guramrit Singh
The paper shows that UPF3A and UPF3B can activate NMD independently of EJC binding in human cells, challenging the idea that UPF3 is solely a bridge between the EJC and UPF complex.
bioRxiv · Jul 2, 2021 · PreprintMolecular Biology