Zhongxia Yi

The paper shows that UPF3A and UPF3B can activate NMD independently of EJC binding in human cells, challenging the idea that UPF3 is solely a bridge between the EJC and UPF complex.

The paper identifies stop codon-proximal 3′UTR introns as a new class of EJC-regulated NMD targets that influence vertebrate development.

The paper shows the exon junction complex (EJC) undergoes a compositional switch from an SR-rich to an SR-devoid form, altering mRNP structure and NMD activity.