Guramrit Singh

circPCMTD1: A protein-coding circular RNA that regulates DNA damage response in BCR/ABL-positive leukemias

This study identifies circPCMTD1 as a circular RNA that promotes leukemic cell proliferation by enhancing DNA damage response tolerance through a novel peptide product.

PYM1 limits non-canonical Exon Junction Complex occupancy in a gene architecture dependent manner to tune mRNA expression

This study shows PYM1 regulates EJC occupancy in a gene architecture-dependent manner, affecting mRNA stability and decay, and is exploited by flaviviruses to alter host mRNA regulation.

Direct and indirect effects of spliceosome disruption compromise gene regulation by Nonsense-Mediated mRNA Decay

The paper shows that disrupting the spliceosome upregulates NMD targets, with some spliceosome components directly affecting NMD.

Sm-site containing mRNAs can accept Sm-rings and are downregulated in Spinal Muscular Atrophy

The paper identifies Sm-site containing mRNAs that can accept Sm-rings and shows their downregulation in Spinal Muscular Atrophy.

Mammalian UPF3A and UPF3B activate NMD independently of their EJC binding

The paper shows that UPF3A and UPF3B can activate NMD independently of EJC binding in human cells, challenging the idea that UPF3 is solely a bridge between the EJC and UPF complex.

Stop codon-proximal 3′UTR introns in vertebrates can elicit EJC-dependent Nonsense-Mediated mRNA Decay

The paper identifies stop codon-proximal 3′UTR introns as a new class of EJC-regulated NMD targets that influence vertebrate development.

The exon junction complex undergoes a compositional switch that alters mRNP structure and nonsense-mediated mRNA decay activity

The paper shows the exon junction complex (EJC) undergoes a compositional switch from an SR-rich to an SR-devoid form, altering mRNP structure and NMD activity.